There's nothing quite like falling asleep when you have the Mississippi River nearby. If that's also on your list of "things you'd like to experience on a getaway", I found a place in Hamilton, Illinois that offers that and also an orchard view.
Sometimes to figure out where you're going, you need to explore where you've been. There is history available to explore in southern Illinois at a secluded cabin that happens to sit along the Trail of Tears in Shawnee Forest.
I don't know about you, but when I think of I-70, I don't think of relaxing. However, there is one tiny house cabin that's hidden in a cove just off the interstate that does appear to offer a lot of relaxation options.